Gas pressure regulating boxes are the core equipment of the urban gas transmission and distribution system, and their safe and stable operation relates to user gas consumption and social public safety. Based on the large-scale pressure regulating box shut-off events occurring within the gas supply scope of a city gas enterprise in western China, this paper analyzed the causes of pressure regulating box shut-offs under extreme gale weather. This paper determined that the severe air pressure fluctuation and short-term sudden temperature change caused by extreme gales are the main inducements. Furthermore, this paper explained the event mechanism based on the basic variation relationship between atmospheric pressure and gauge pressure, and finally proposed targeted preventive and response strategies. This provides practical reference for improving the extreme weather adaptability of gas pressure regulating equipment and ensuring the stable supply of urban gas.